Highlight report: hepatotoxicity prediction with Hep3B cells

Highlight report: Metabolomics in hepatotoxicity testing

The protective effects of epigallocatechin gallate on lipopolysa ccharide-induced hepatotoxicity: an in vitro study on Hep3B cells

Objective(s): In the present study, our aim was to investigate the possible protective effects of epigallocatechin gallate (EGCG) on lipopolysaccharide (LPS)-induced hepatotoxicity by using Hep3B human hepatoma cells. Specifically, the study examines the role of some proinflammatory markers and oxidative damage as possible mechanisms of LPS-associated cytotoxicity. Consequently, the hepatocellu...

Highlight report: Cardiotoxicity screening

have published a review about identification of cardiotoxic compounds by rapid screening methods (Li et al., 2015). Cardiotoxicity is one of the most frequent causes for withdrawal of drugs from the market and also during drug development (MacDonald and Robertson, 2009; Apostolakis et al., 2013; Li et al., 2015). Totally, 81 drugs have been taken from the market between 1990 and 2013 (Li et al....

Highlight report: Blueprint for stem cell differentiation into liver cells

Stem cell research is of high interest, because precursor cells can be directed to differentiate into practically all mature cell types. This represents a potential perspective for therapeutics of severely damaged organs and also an alternative to animal drug and toxicity testing. Nonetheless, an essential question still remains: How similar are differentiated stem cells to the desired mature c...

The protective effects of epigallocatechin gallate on lipopolysa ccharide-induced hepatotoxicity: an in vitro study on Hep3B cells

OBJECTIVES In the present study, our aim was to investigate the possible protective effects of epigallocatechin gallate (EGCG) on lipopolysaccharide (LPS)-induced hepatotoxicity by using Hep3B human hepatoma cells. Specifically, the study examines the role of some proinflammatory markers and oxidative damage as possible mechanisms of LPS-associated cytotoxicity. Consequently, the hepatocellular...